N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride

Base Information

• Chemical Name: N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride
• CAS No.: 86260-64-2
• Molecular Formula: C₂₅H₂₇Cl₂N₇O*2ClH
• Molecular Weight: 585.364

Synonyms:N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride

Chemical Property of N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride

Chemical Property:

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Technology Process of N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride

There total 4 articles about N²-(5,6-dichloro-1Hbenzimidazol-2-yl)-N⁴-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-chloro-N-(5,6-dichloro-1H-benzimidazol-2-yl)-5,6,7,8-tetrahydro-2-quinazolinamine (86260-74-4) + 5-amino-N-ethyl-2-methoxybenzenemethanamine dihydrochloride (51388-03-5) → N2-(5,6-dichloro-1Hbenzimidazol-2-yl)-N4-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride (86260-64-2)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 3h;

DOI:10.1021/jm00363a017

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → N2-(5,6-dichloro-1Hbenzimidazol-2-yl)-N4-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride (86260-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / conc. HCl / 2-ethoxy-ethanol / 24 h / Heating

2: POCl₃ / 1.5 h / 100 °C

3: 83 percent / dimethylformamide / 3 h / 110 °C

With hydrogenchloride; trichlorophosphate; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00363a017

Reference yield:

(5,6,7,8-tetrahydro-4-hydroxy-2-quinazolinyl)cyanamide (86260-73-3) → N2-(5,6-dichloro-1Hbenzimidazol-2-yl)-N4-<3-<(ethylamino)methyl>-4-methoxyphenyl>-5,6,7,8-tetrahydro-2,4-quinazolinediamine dihydrochloride (86260-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / conc. HCl / 2-ethoxy-ethanol / 24 h / Heating

2: POCl₃ / 1.5 h / 100 °C

3: 83 percent / dimethylformamide / 3 h / 110 °C

With hydrogenchloride; trichlorophosphate; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00363a017

upstream raw materials:

4-chloro-N-(5,6-dichloro-1H-benzimidazol-2-yl)-5,6,7,8-tetrahydro-2-quinazolinamine

5-amino-N-ethyl-2-methoxybenzenemethanamine dihydrochloride

4,5-Dichloro-1,2-phenylenediamine

(5,6,7,8-tetrahydro-4-hydroxy-2-quinazolinyl)cyanamide

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