Technology Process of C46H57N3O9
There total 25 articles about C46H57N3O9 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3S,4S)-4-(dibenzylamino)-3-hydroxy-2-methyl-5-(pyridin-3-yl)pentanoic acid;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
C21H31NO7;
With
dmap;
In
tetrahydrofuran; toluene;
at -78 - 0 ℃;
for 46h;
- Guidance literature:
-
With
dmap;
In
toluene;
at -78 - 0 ℃;
for 45.9h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/ml300385q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C / Molecular sieve; Inert atmosphere; Schlenk technique
2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique
3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique
4.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane; hexane / 3 h / -78 °C / Inert atmosphere; Schlenk technique
4.2: 4.3 h / -78 - 0 °C
5.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique
6.1: triethylamine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Schlenk technique
7.1: dmap / toluene / 45.9 h / -78 - 0 °C / Inert atmosphere; Schlenk technique
With
dmap; lithium aluminium tetrahydride; lithium hydroxide monohydrate; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1021/ml300385q
