1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

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Chemical Name:1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone
CAS No.:903550-99-2
Molecular Formula:C₃₁H₃₂FNO₁₀
Molecular Weight:597.594
Hs Code.:

Synonyms:1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

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Chemical Property of 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

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Technology Process of 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

There total 5 articles about 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

: 903550-98-1
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindole

: 16331-45-6
p-ethylbenzoyl chloride

: 903550-99-2
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ml400339b

Reference yield:

: 552866-98-5
2,3-dihydro-4-fluoro-1H-indole

: 903550-99-2
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; water / 38 h / Reflux; Inert atmosphere

2: pyridine; dmap / chloroform / 96 h / 20 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; 1,4-dioxane / 72 h / 20 °C

4: aluminum (III) chloride / dichloromethane / 1 h / 0 °C

With pyridine; dmap; aluminum (III) chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; ethanol; dichloromethane; chloroform; water; 4: |Friedel-Crafts Acylation;
DOI:10.1021/ml400339b

Reference yield:

: 903550-97-0
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindoline

: 903550-99-2
1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone

Guidance literature:: Multi-step reaction with 2 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; 1,4-dioxane / 72 h / 20 °C

2: aluminum (III) chloride / dichloromethane / 1 h / 0 °C

With aluminum (III) chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; dichloromethane; water; 2: |Friedel-Crafts Acylation;
DOI:10.1021/ml400339b