Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

Base Information

Chemical Name:Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester
CAS No.:163333-48-0
Molecular Formula:C₅₃H₉₂Cl₂N₂O₈
Molecular Weight:956.228
Hs Code.:

Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

Synonyms:Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

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Chemical Property of Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

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Technology Process of Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

There total 3 articles about Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1042289-75-7
rac-1,2-dipalmitoylglycerol

: 79145-92-9
N-((tert-butoxy)carbonyl)-4-(bis(2-chloroethyl)amino)-L-phenylalanine

: 163333-48-0
Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0223-5234(97)89087-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 163333-48-0
Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaOH / H₂O; dioxane / 16 h / Ambient temperature

2: 37 percent / BOP, HOBt, DIPEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0223-5234(97)89087-3

Reference yield:

: 148-82-3,8057-25-8
L-PAM

: 163333-48-0
Hexadecanoic acid 2-((S)-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-2-tert-butoxycarbonylamino-propionyloxy)-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaOH / H₂O; dioxane / 16 h / Ambient temperature

2: 37 percent / BOP, HOBt, DIPEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0223-5234(97)89087-3