2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester
• CAS No.: 1181669-62-4
• Molecular Formula: C₁₄H₁₅NO₆
• Molecular Weight: 293.276
• Mol file: 1181669-62-4.mol

Synonyms:2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Chemical Property of 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

There total 3 articles about 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2-methyl-5-nitrobenzylidene)malonic acid dimethyl ester (1181669-59-9) + trimethylsulfoxonium iodide (1774-47-6) → 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester (1181669-62-4)

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; Inert atmosphere;

2-(2-methyl-5-nitrobenzylidene)malonic acid dimethyl ester; In dimethyl sulfoxide; mineral oil; Inert atmosphere;

DOI:10.1021/ol901454y

Reference yield:

2-methyl-5-nitro-benzaldehyde (16634-91-6) → 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester (1181669-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperdinium acetate / benzene / 22 h / Inert atmosphere; Reflux

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

2.2: Inert atmosphere

With piperdinium acetate; sodium hydride; In dimethyl sulfoxide; mineral oil; benzene;

DOI:10.1021/ol901454y

Reference yield:

malonic acid dimethyl ester (108-59-8) → 2-(2-methyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester (1181669-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperdinium acetate / benzene / 22 h / Inert atmosphere; Reflux

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

2.2: Inert atmosphere

With piperdinium acetate; sodium hydride; In dimethyl sulfoxide; mineral oil; benzene;

DOI:10.1021/ol901454y

upstream raw materials:

2-(2-methyl-5-nitrobenzylidene)malonic acid dimethyl ester

trimethylsulfoxonium iodide

2-methyl-5-nitro-benzaldehyde

malonic acid dimethyl ester

Downstream raw materials:

2-(2-bromomethyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

2-(2-formyl-5-nitrophenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester