5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

Base Information

Chemical Name:5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine
CAS No.:129395-82-0
Molecular Formula:C₄₄H₄₉N₄O₁₃PS
Molecular Weight:904.932
Hs Code.:

Synonyms:5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

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Technology Process of 5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

There total 2 articles about 5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 112514-65-5
5'-O-(dimethoxytrityl)thymidine 3'-O-(2''-cyanoethylmethylphosphonothioate)

: 14046-57-2
3'-O-acetyl-5'-deoxy-5'-iodothymidine

: 129395-82-0
5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

Guidance literature:: In N,N-dimethyl-formamide; acetonitrile; at 50 ℃; for 6h;
DOI:10.1016/S0040-4039(00)94646-X

Reference yield:

: 115393-52-7
5'-O-dimethoxytritylthymidine-3'-O-β-cyanoethoxymethylphosphonite

: 129395-82-0
5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1: S₈

2: 70 percent / dimethylformamide; acetonitrile / 6 h / 50 °C

With sulfur; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)94646-X