115393-52-7

Upstream product

• 114079-04-8 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite 
• 109-78-4 3-Hydroxypropionitrile 
• 407-25-0 trifluoroacetic anhydride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 112514-65-5 5'-O-(dimethoxytrityl)thymidine 3'-O-(2''-cyanoethylmethylphosphonothioate) 
• 191474-13-2 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine 
• 1246936-63-9 Li 5'-Dimethoxytritylthymidyl-3'-methylphosphonothioate 
• 129395-82-0 5'-Dimethoxytritylthymidyl-(3'-5')-methylphosphono-5'-thio-3'-acetylthymidine 
• 188944-93-6 Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester 
• 40615-39-2 1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)- dione 

Relevant academic research and scientific papers

A new DMAP-catalyzed phosphonamidite coupling reaction for synthesis of oligonucleotide methylphosphonate derivatives

4-N,N-dimethylaminopyridine (DMAP) catalyzed coupling of 5′-dimethoxy-tritylthymidyl-3′-methylphosphonoamidite and 5′-trifluoroacetyl-3′-acetylthymidine and subsequent oxidation produce dinucleoside methyl phosphonate in a new, less water sensitive coupling reaction.

PHOSPHORAMIDITES AS SYNTHONS FOR POLYNUCLEOTIDE SYNTHESIS

Methods for the rapid synthesis of DNA and RNA are described.The procedures involve using nucleoside phosphoramidites as synthons and silica as a polymeric support.Additionally, a novel reaction involving nucleoside O-alkyl methylphosphonothioates is described.