2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER

Base Information

• Chemical Name: 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER
• CAS No.: 157490-62-5
• Molecular Formula: C₁₂H₁₅NO₆
• Molecular Weight: 269.254
• Mol file: 157490-62-5.mol

Synonyms:2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-dimethyl ester

Chemical Property of 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER 95.00% ^*data from reagent suppliers

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Technology Process of 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER

There total 2 articles about 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

Glyoxilic acid (298-12-4) + methyl 3-aminocrotonate (14205-39-1) → 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-dimethyl ester (157490-62-5)

Guidance literature:

DOI:10.1016/j.molstruc.2014.06.044

Reference yield: 12.6%

n-propyl acetoacetate (1779-60-8) + methyl (E)-3-aminocrotonate (14205-39-1) + Glyoxilic acid (298-12-4) → 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-dimethyl ester (157490-62-5) + 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-dipropyl ester (157490-63-6) + 3-(methoxycarbonyl)-2,6-dimethyl-5-(propoxycarbonyl)-1,4-dihydro-4-pyridinecarboxylic acid (510755-86-9,510755-93-8,510755-97-2)

Guidance literature:

n-propyl acetoacetate; Glyoxilic acid; With morpholine; In ethanol; water; at 20 ℃; for 16h;

With acetic anhydride; for 0.5h;

methyl (E)-3-aminocrotonate; In ethyl acetate; for 16h; cooling;

DOI:10.1016/S0957-4166(02)00655-9

Reference yield: 86.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-dimethyl ester (157490-62-5) → pentafluorophenyl 2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydroisonicotinate

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/0223-5234(94)90103-1

upstream raw materials:

n-propyl acetoacetate

methyl (E)-3-aminocrotonate

Glyoxilic acid

methyl 3-aminocrotonate

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