1779-60-8

Basic information

• Product Name: ACETOACETIC ACID N-PROPYL ESTER
• Synonyms: PROPYL ACETOACETATE;3-oxo-butanoicacipropylester;Propyl 3-oxobutanoate;Propyl ester of 3-oxobutanoic acid;ACETOACETIC ACID N-PROPYL ESTER;ACETOACETIC ACID PROPYL ESTER;Acetoacetic n-propyl ester;3-Oxobutanoic acid propyl ester
• CAS NO: 1779-60-8
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• EINECS: 217-223-6
• Mol File: 1779-60-8.mol
• Article Data: 31

Chemical Properties

• Melting Point: 158-160 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 194 °C
• Flash Point: 73.2 °C
• Appearance: /
• Density: 1.01
• Vapor Pressure: 0.475mmHg at 25°C
• Refractive Index: 1.4200-1.4240
• PKA: 10.69±0.46(Predicted)
• CAS DataBase Reference: ACETOACETIC ACID N-PROPYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACETOACETIC ACID N-PROPYL ESTER(1779-60-8)
• EPA Substance Registry System: ACETOACETIC ACID N-PROPYL ESTER(1779-60-8)

Safety Data

• Hazardous Substances Data: 1779-60-8(Hazardous Substances Data)

Usage

Uses

Propyl Acetoacetate is used as a reagent in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists.

InChI:InChI=1/C7H12O3/c1-3-4-10-7(9)5-6(2)8/h3-5H2,1-2H3

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 71-23-8 propan-1-ol 
• 109-60-4 1-Propyl acetate 
• 6819-41-6 sodium n-propoxide 
• 141-97-9 ethyl acetoacetate 
• 2911-21-9 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 60-29-7 diethyl ether 
• 1694-31-1 tert-butyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 1883-42-7 tris(n-propoxycarbonylmethyl)stibine 
• 75-36-5 acetyl chloride 
• 42490-66-4 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 591-60-6 butyl acetoacetate 

Downstream Products

• 96918-82-0 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-cyclopropylmethyl ester 5-propyl ester 
• 95549-60-3 2,5-dipropylformate 1,4-cyclohexanedione 
• 63780-41-6 (E)-3-(2-Amino-4-chloro-phenylamino)-but-2-enoic acid propyl ester 
• 364620-13-3 (±)-propyl 6-methyl-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 57508-37-9 propyl 3-(benzylamino)but-2-enoate 
• 1117-52-8 6,10,14-trimethyl-5,9,13-pentadecatriene-2-on 
• 63780-42-7 (E)-3-(2-Amino-4-bromo-phenylamino)-but-2-enoic acid propyl ester 
• 63780-40-5 (E)-3-(2-Amino-4-methyl-phenylamino)-but-2-enoic acid propyl ester 

Relevant articles and documents

Probing the effects of microwave irradiation on enzyme-catalysed organic transformations: The case of lipase-catalysed transesterification reactions

The lipase-catalysed transesterification reaction of methyl acetoacetate in toluene as a solvent has been studied using carefully controlled conditions. Results suggest that microwave heating does not have a noticeable effect on reaction rate or product conversion. This journal is The Royal Society of Chemistry.

Synthesis and evaluation of pharmacological activities of 3,5-dialkyl 1,4-dihydro-2,6-dimethyl-4-nitroimidazole-3,5-pyridine dicarboxylates

New analogues of nifedipine, in which the 2-nitrophenyl group at position 4 is replaced by a 1 -methyl-5-nitro-2-imidazolyl substituent, were synthesized. The symmetrical dialkyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3, 5-pyridinedicarboxylates were prepared by a classical Hantzsch condensation. The asymmetrical analogues were synthesized using a procedure reported by Iwanami that involved the condensation of alkylacetoacetate with methyl-, ethyl- or isopropyl-3-aminocrotonate and 1 -methyl-5-nitroimidazole-2-carboxaldehyde. Calcium channel antagonist activities were determined in vitro using a guinea pig ileum longitudinal smooth muscle (GPILSM) assay. Many compounds exhibited superior, or equipotent, calcium antagonist activity (IC50 = 10- 10 to 10-13 M range) relative to the reference drug nifedipine (IC50 = 1.09? 0.12 × 10-11 M). Antinociceptive effects of some compounds were evaluated by the mouse tail-flick assay in vivo. Results demonstrate that some of the compounds were active as an antinociceptive.

N, N’-dimethyl formamide (DMF) mediated Vilsmeier–Haack adducts with 1,3,5-triazine compounds as efficient catalysts for the transesterification of β-ketoesters

N, N’-dimethyl formamide (DMF) mediated Vilsmeier–Haack (VH) adducts with 1,3,5-triazine compunds such as trichloroisocyanuric acid (TCCA) and trichlorotriazine (TCTA) were prepared by replacing classical oxy chlorides POCl3, and SOCl2, which were explored as efficient catalysts for the transesterification of β-ketoesters. The prepared (TCCA/DMF) and (TCTA/DMF) adducts improved greenery of the classical Vilsmeier–Haack reagents (POCl3/DMF), and (SOCl2/DMF), and demonstrated their better efficient catalytic ativity. Reaction times were in the range: 3.5 to 6.5 hr (SOCl2/DMF); 2.8–5.2 hr (POCl3/DMF); 2.5–5.2 hr (TCCA/DMF) and 2.5–5.0 hr (TCTA/DMF) catalytic systems. Ultrasonically (US) assisted protocols with these reagents further reduced the reaction times (two to three times), while microwave assisted (MW) protocols with these reagents were much more effective. The reactions could be completed in only few seconds (less than a minute) in MWassisted protocols as compared to US assited reactions, followed by good product yields.

Copper-catalyzed radical coupling of 1,3-dicarbonyl compounds with terminal alkenes for the synthesis of tetracarbonyl compounds

A novel and efficient copper-catalyzed radical cross-coupling of 1,3-dicarbonyl compounds with terminal alkenes for the synthesis of tetracarbonyl compounds with a quaternary carbon atom has been developed. Mechanistically, this transformation involves the construction of two C-C bonds and two CO bonds in a one-pot process. The reaction tolerates a wide range of functional groups and proceeds under mild conditions.