Technology Process of tert-Butyl-{4-[2-((2S,3R)-3-iodomethyl-oxiranyl)-ethyl]-4-vinyl-hex-5-enyloxy}-diphenyl-silane
There total 13 articles about tert-Butyl-{4-[2-((2S,3R)-3-iodomethyl-oxiranyl)-ethyl]-4-vinyl-hex-5-enyloxy}-diphenyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; iodine; triphenylphosphine;
In
benzene;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol034020s
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / DIBAl-H / tetrahydrofuran; hexane / 0.5 h / 0 °C
2: 92 percent / L-(+)-DIPT; molecular sieves 4 Angstroem; TBHP / Ti(i-PrO)4 / CH2Cl2 / -25 - 20 °C
3: 95 percent / triphenylphosphine; I2; imidazole / benzene / 0.5 h / 20 °C
With
1H-imidazole; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; 4 A molecular sieve; iodine; diisobutylaluminium hydride; triphenylphosphine;
titanium(IV) isopropylate;
In
tetrahydrofuran; hexane; dichloromethane; benzene;
2: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1021/ol034020s
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 91 percent / H2O2 / tetrahydrofuran / 1 h / 20 °C
2: 100 percent / aq. HCl / ethanol / 2 h / 20 °C
3: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.5 h / 20 °C
4: 89 percent / benzene / 5 h / Heating
5: 100 percent / DIBAl-H / tetrahydrofuran; hexane / 0.5 h / 0 °C
6: 92 percent / L-(+)-DIPT; molecular sieves 4 Angstroem; TBHP / Ti(i-PrO)4 / CH2Cl2 / -25 - 20 °C
7: 95 percent / triphenylphosphine; I2; imidazole / benzene / 0.5 h / 20 °C
With
1H-imidazole; hydrogenchloride; tert.-butylhydroperoxide; oxalyl dichloride; L-(+)-diisopropyl tartrate; 4 A molecular sieve; dihydrogen peroxide; iodine; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
titanium(IV) isopropylate;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; benzene;
4: Wittig reaction / 6: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1021/ol034020s
