5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Base Information

Chemical Name:5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile
CAS No.:1201447-13-3
Molecular Formula:C₂₃H₂₄N₄O₃
Molecular Weight:404.469
Hs Code.:

Synonyms:5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

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Chemical Property of 5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

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Technology Process of 5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

There total 8 articles about 5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5-(3-(1-((2-hydroxyethyl)imino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

: 1201447-13-3,1306760-86-0,1306760-87-1
5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: With sodium tetrahydroborate; ethanol; In dichloromethane; at 0 - 40 ℃; for 1h;

Reference yield: 23.0%

: 1201447-05-3
5-(3-(1-hydroxy-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

: 141-43-5
ethanolamine

: 1201447-13-3,1306760-86-0,1306760-87-1
5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: 5-(3-(1-hydroxy-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile; With pyridine; thionyl chloride; In dichloromethane; at 0 - 20 ℃;

ethanolamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 60 ℃;

Reference yield:

: 5’,5’-dimethyl-2,3-dihydrospiro[indene-1,2’-[1,3]dioxane]-4-carbonitrile

: 1201447-13-3,1306760-86-0,1306760-87-1
5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 48 h / 25 °C

2.1: 1,1'-carbonyldiimidazole / 1 h / 55 °C

2.2: 12 h / 80 °C

3.1: toluene-4-sulfonic acid / acetone / 2 h / 25 °C

4.1: toluene-4-sulfonic acid / ethanol; toluene / 12 h / Reflux; Dean-Stark; Molecular sieve

5.1: sodium tetrahydroborate; ethanol / dichloromethane / 1 h / 0 - 40 °C

With sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; toluene-4-sulfonic acid; triethylamine; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane; acetone; toluene;