8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

Base Information

Chemical Name:8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide
CAS No.:108653-89-0
Molecular Formula:C₂₇H₄₀O₃SeSi
Molecular Weight:519.658
Hs Code.:

Synonyms:8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

Suppliers and Price of 8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

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Technology Process of 8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

There total 5 articles about 8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5707-04-0
Phenylselenyl chloride

: 108653-88-9
8α-tert-butyldimethylsilyloxy-6,11β,7αH-eudesm-4-en-12,6-olide

: 108653-89-0
8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; 1 h, -78 degC then 45 min, -78 degC then 45 min at -40 degC;
DOI:10.1016/S0040-4020(01)87333-6

Reference yield:

: 481-05-0,1750-99-8,17367-67-8,46961-87-9,96847-33-5,103617-15-8
artemisin

: 108653-89-0
8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / H₂ / Wilkinson catalyst / benzene; ethanol / 12 h / Ambient temperature

2: 90 percent / BF₃*OEt₂ / acetic acid / 5 h / Ambient temperature

3: 83 percent / W-2 Raney nickel / methanol / 3 h / Ambient temperature

4: 90 percent / imidazole / dimethylformamide / 6 h / 40 °C

5: 82 percent / nBuLi, diisopropylamine / hexane; tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h, -78 degC then 45 min, -78 degC then 45 min at -40 degC

With 1H-imidazole; n-butyllithium; W-2 Raney nickel; boron trifluoride diethyl etherate; hydrogen; diisopropylamine; Wilkinson's catalyst; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)87333-6

Reference yield:

: 108653-85-6
8α-hydroxy-6,11β,7αH-eudesma-2,4-dien-6,12-olide

: 108653-89-0
8α-tert-butyldimethylsilyloxy-11β-phenylseleno-6β7αH-eudesm-4-en-12,6-olide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 5percent Pd/C / ethyl acetate; methanol / 0.5 h / Ambient temperature

2: 90 percent / imidazole / dimethylformamide / 6 h / 40 °C

3: 82 percent / nBuLi, diisopropylamine / hexane; tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h, -78 degC then 45 min, -78 degC then 45 min at -40 degC

With 1H-imidazole; n-butyllithium; hydrogen; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87333-6