(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

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Chemical Name:(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid
CAS No.:1542166-97-1
Molecular Formula:C₅₀H₆₄N₆O₁₁
Molecular Weight:925.092
Hs Code.:

(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

Synonyms:(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

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Chemical Property of (S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

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Technology Process of (S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

There total 15 articles about (S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1542166-96-0
tert-butyl 2-((5S,8S)-6-(tert-butyloxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tert-butyloxycarbonyl)amino)-5-methylpyrimidine-4-carboxylate

: 1542166-97-1
(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

Guidance literature:: With Jones reagent; In acetone; at 0 ℃; for 1h;
DOI:10.1021/ja412298c

Reference yield:

: 1313532-22-7
3-tert-butyl 5-ethyl 4-methyl-1H-pyrazole-3,5-dicarboxylate

: 1542166-97-1
(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 0.5 h / 25 °C

2.1: silver nitrate; [bis(acetoxy)iodo]benzene / water; dichloromethane / 2 h / 25 °C

3.1: acetonitrile / 15 h / 25 °C / Molecular sieve

4.1: triethylamine / tetrahydrofuran / 12 h / 50 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.17 h / 0 °C

6.1: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

7.1: toluene-4-sulfonic acid / methanol / 3 h / 25 °C

8.1: Jones reagent / acetone / 1 h / 0 °C

With Jones reagent; [bis(acetoxy)iodo]benzene; diphenyl phosphoryl azide; potassium tert-butylate; water; toluene-4-sulfonic acid; silver nitrate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; acetone; acetonitrile; 3.1: |Diels-Alder Cycloaddition / 6.1: |Curtius Rearrangement;
DOI:10.1021/ja412298c

Reference yield:

: 1542166-88-0
3-(tert-butyl) 5-ethyl 1-amino-4-methyl-1H-pyrazole-3,5-dicarboxylate

: 1542166-97-1
(S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)-5-methylpyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydrogencarbonate; iodine / water; dichloromethane / 2 h / 25 °C

2: acetonitrile / 15 h / 25 °C / Molecular sieve

3: triethylamine / tetrahydrofuran / 12 h / 50 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 0.17 h / 0 °C

5: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

6: toluene-4-sulfonic acid / methanol / 3 h / 25 °C

7: Jones reagent / acetone / 1 h / 0 °C

With Jones reagent; diphenyl phosphoryl azide; water; iodine; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile; 2: |Diels-Alder Cycloaddition / 5: |Curtius Rearrangement;
DOI:10.1021/ja412298c