4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

Base Information

Chemical Name:4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline
CAS No.:289700-98-7
Molecular Formula:C₂₆H₃₁BrN₆O₅
Molecular Weight:587.473
Hs Code.:

Synonyms:4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

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Chemical Property of 4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

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Technology Process of 4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

There total 1 articles about 4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 132710-90-8
4-(3-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester

: 174709-17-2
4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline

: 289700-98-7
4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.25h; Heating / reflux;

Reference yield: 88.0%

: 289700-98-7
4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline

: 289700-92-1
4-[(3-bromophenyl)amino]-6-nitro-7-[3-(piperazin-1-yl)propyloxy]-quinazoline

Guidance literature:: 4-[(3-bromophenyl)amino]-6-nitro-7-{3-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]propyloxy}-quinazoline; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydroxide; In dichloromethane; water;