N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Base Information

Chemical Name:N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine
CAS No.:174709-17-2
Molecular Formula:C14H8BrFN4O2
Molecular Weight:363.146
Hs Code.:
Mol file:174709-17-2.mol

Synonyms:4-[(3-bromophenyl)amino]-7-fluoro-6-nitroquinazoline;(3-Bromo-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine;4-[(3- bromophenyl)amino]-7-fluoro-6-nitro-quinazoline;4-(3-bromophenylamino)-7-fluoro-6-nitroquinazoline;

Suppliers and Price of N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Chemical Property:

Melting Point:196 - 198 °C
PSA：83.63000
LogP:4.77940

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine

There total 4 articles about N-(3-bromophenyl)-7-fluoro-6-nitroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 591-19-5
m-Bromoaniline

: 162012-70-6
4-chloro-7-fluoro-6-nitroquinazoline

: 174709-17-2
4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline

Guidance literature:: With triethylamine; In dichloromethane; isopropyl alcohol; at 20 ℃;
DOI:10.1002/anie.201703154

Reference yield:

: 162012-69-3
7-fluoro-6-nitro-3H-quinazolin-4-one

: 174709-17-2
4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; DMF

2: propan-2-ol; CH₂Cl₂ / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm0580196

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 174709-17-2
4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 2-methoxy-ethanol / 18 h / Reflux

2: sulfuric acid; nitric acid / 2 h / 0 - 110 °C

3: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

4: dichloromethane; ethanol / 0.5 h / 20 °C

With thionyl chloride; sulfuric acid; nitric acid; N,N-dimethyl-formamide; In ethanol; dichloromethane; 2-methoxy-ethanol;
DOI:10.1021/ml4002437