Technology Process of triethylsilyl ether of 13-cis-retinol
There total 9 articles about triethylsilyl ether of 13-cis-retinol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride; titanium(III) chloride;
In
tetrahydrofuran;
for 0.5h;
Ambient temperature;
DOI:10.1016/S0040-4039(00)80055-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) HMPA, 0 deg C, 1 h, 2.) 20 min
2: 1.) ethylmagnesium bromide / 1.) THF, room temperature, 1 h, 2.) 15 min
3: 75 percent / DIBAH / tetrahydrofuran; toluene / 0.5 h / -78 °C
4: 90 percent / H2 / Lindlar catalyst / methanol / 24 h
5: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
6: 90 percent / LiAlH4, TiCl3 / tetrahydrofuran / 0.5 h / Ambient temperature
With
1H-imidazole; lithium aluminium tetrahydride; titanium(III) chloride; ethylmagnesium bromide; hydrogen; sodium hydride; diisobutylaluminium hydride;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00272a032
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) ethylmagnesium bromide / 1.) THF, room temperature, 1 h, 2.) 15 min
2: 75 percent / DIBAH / tetrahydrofuran; toluene / 0.5 h / -78 °C
3: 90 percent / H2 / Lindlar catalyst / methanol / 24 h
4: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
5: 90 percent / LiAlH4, TiCl3 / tetrahydrofuran / 0.5 h / Ambient temperature
With
1H-imidazole; lithium aluminium tetrahydride; titanium(III) chloride; ethylmagnesium bromide; hydrogen; diisobutylaluminium hydride;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00272a032
