3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

Base Information

Chemical Name:3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin
CAS No.:75017-77-5
Molecular Formula:C₁₉H₂₀N₄O₂
Molecular Weight:336.393
Hs Code.:

Synonyms:3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

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Chemical Property of 3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

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Technology Process of 3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

There total 4 articles about 3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 85147-32-6
<2-(2-Brommethyl-4-methyl-1-piperazinyl)-5-nitrophenyl>phenylmethanon

: 75017-77-5
3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

Guidance literature:: With ammonia; In ethanol; at 100 ℃; for 74h; in autoclave;
DOI:10.1002/hlca.19820650719

Reference yield:

: 34052-37-4
2-chloro-5-nitrobenzophenone

: 75017-77-5
3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / N-ethyldiisopropylamine, N-methyl-2-pyrrolidone / 15 h / 150 °C

2: 90 percent / SOBr₂ / CHCl₃ / 3 h / Heating

3: 78 percent / NH₃(liq.) / ethanol / 74 h / 100 °C / in autoclave

With 1-methyl-pyrrolidin-2-one; sulfurous dibromide; ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; chloroform;
DOI:10.1002/hlca.19820650719

Reference yield:

: 85147-30-4
<2-(2-Hydroxymethyl-4-methylpiperazinyl)-5-nitrophenyl>phenylmethanon

: 75017-77-5
3-Methyl-9-nitro-7-phenyl-1,2,3,4,4a,5-hexahydropyrazino<1,2-a><1,4>benzodiazepin

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / SOBr₂ / CHCl₃ / 3 h / Heating

2: 78 percent / NH₃(liq.) / ethanol / 74 h / 100 °C / in autoclave

With dibromo sulfoxide; ammonia; In ethanol; chloroform;
DOI:10.1002/hlca.19820650719