34052-37-4Relevant articles and documents
Preparation method of 2-chloro-5-nitrobenzophenone
-
Paragraph 0021; 0022; 0023; 0024, (2017/02/24)
The invention provides a preparation method of 2-chloro-5-nitrobenzophenone. The method sequentially comprises the following steps: (1) by using benzene as a raw material and halohydrocarbons as a solvent, carrying out condensation with 2-chloro-5-nitrobenzoyl chloride under the action of a catalyst at -20 to -15 DEG C; (2) after the reaction finishes, adding an acid to perform treatment; and (3) filtering, and crystallizing to obtain the 2-chloro-5-nitrobenzophenone. The preparation method has the advantages of short reaction time and mild reaction conditions, and thus, has high safety and simple operational process. The obtained product has high purity. The method does not use any harmful solvent to the environment, is low in production cost, and thus, is suitable for industrial production.
Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides
Parlow, John J.,Mischke, Deborah A.,Woodard, Scott S.
, p. 5908 - 5919 (2007/10/03)
The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.
Sulphonamides derived from diarylmethanes, the processes for preparing them and pharmaceutical compositions containing them
-
, (2008/06/13)
The invention relates to new compounds corresponding to formula I: STR1 in which: W represents C=O, CH2 or CHOH, Z represents STR2 R1 and R2 represent especially Cl or F, R, R' and R" represent especially H, X represents especially CH2, Y represents especially COOH, u and v are two integers ranging from 0 to 10, p and q take the value 0 or 1, n and m are two integers ranging 0 to 10 and t is 0 or 1 the total number of carbon atoms in the chain STR3 ranging from 2 to 20, and to their physiologically acceptable salts obtained with organic or inorganic acids. These compounds are useful for preparing medicinal products which have, especially, anti-inflammatory properties.