(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

Base Information

Chemical Name:(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one
CAS No.:1242985-37-0
Molecular Formula:C₂₂H₂₂ClNO₃
Molecular Weight:383.875
Hs Code.:

Synonyms:(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

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Technology Process of (R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

There total 5 articles about (R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 30626-03-0
(3E)-4-(4-chlorophenyl)-3-buten-2-one

: 5632-87-1,70050-92-9,121470-62-0,34337-10-5
N-benzoylnorvaline

: 1242985-37-0
(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

Guidance literature:: With FBIP-Cl; sodium acetate; silver trifluoromethanesulfonate; acetic anhydride; acetic acid; at 8 - 30 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja106088v

Reference yield:

: 3160-40-5
4-(4-chlorophenyl)-3-buten-2-one

: 7682-15-7,15891-50-6,57357-56-9
N-acetylnorvaline

: 1242985-37-0
(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

: C₂₂H₂₂ClNO₃

Guidance literature:: With [RuBIP-Cl]₂; sodium acetate; silver trifluoromethanesulfonate; In acetic anhydride; acetic acid; at 30 ℃; for 23h; Overall yield = 98 %;
DOI:10.1021/cs500393x

Reference yield:

: 760-78-1,498-18-0
2-aminopentanoic acid

: 30626-03-0
(3E)-4-(4-chlorophenyl)-3-buten-2-one

: 93-97-0
benzoic acid anhydride

: 1242985-37-0
(R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

: (S)-4-((S)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one

Guidance literature:: With FBIP-OTf; sodium acetate; benzoic acid; In tetrahydrofuran; toluene; at 70 ℃; for 7h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201200085