(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

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Chemical Name:(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide
CAS No.:1612891-37-8
Molecular Formula:C₂₈H₃₄N₂O₃S
Molecular Weight:478.656
Hs Code.:

Synonyms:(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

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Chemical Property of (S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

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Technology Process of (S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

There total 4 articles about (S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1612891-36-7
C₂₄H₂₅NO₃

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1612891-37-8
(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-35-6
(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethanol⁽²⁾

: 1612891-37-8
(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.83 h / -78 °C / Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

With titanium(IV) tetraethanolate; oxalyl dichloride; In tetrahydrofuran; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation;
DOI:10.1021/jo500832j

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1612891-37-8
(S,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 60 h / 60 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.83 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

With titanium(IV) tetraethanolate; oxalyl dichloride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500832j