Technology Process of 2-chloro-N-[(2R,3R)-1,1,1-trifluoro-3-[(4-methoxybenzyl)amino]-3-phenylpropan-2-yl]acetamide
There total 6 articles about 2-chloro-N-[(2R,3R)-1,1,1-trifluoro-3-[(4-methoxybenzyl)amino]-3-phenylpropan-2-yl]acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
at 0 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1021/jo500832j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere
2: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere
3: hydrogenchloride / methanol; 1,4-dioxane / 70 °C / Sealed tube; Inert atmosphere
4: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere
With
hydrogenchloride; titanium(IV) tetraethanolate; tetramethylammonium fluoride; sodium hydrogencarbonate;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jo500832j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 60 h / 60 °C / Inert atmosphere
2.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 0.83 h / -78 °C / Inert atmosphere
3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere
4.1: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere
5.1: hydrogenchloride / methanol; 1,4-dioxane / 70 °C / Sealed tube; Inert atmosphere
6.1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere
With
hydrogenchloride; titanium(IV) tetraethanolate; oxalyl dichloride; tetramethylammonium fluoride; sodium hydrogencarbonate; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500832j
