Technology Process of N-((8-chloro-2-(5-fluoro-2-(trifluoromethyl)-phenyl)quinolin-3-yl)methyl)-9H-purin-6-amine
There total 7 articles about N-((8-chloro-2-(5-fluoro-2-(trifluoromethyl)-phenyl)quinolin-3-yl)methyl)-9H-purin-6-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
6-chloro-7H-purine;
In
ethanol;
at 100 ℃;
for 22h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexene / 2 h / -78 °C
1.2: 4 h / -78 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; acetonitrile / 14 h / 100 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C
4.1: thionyl chloride / chloroform / 3 h / 20 °C
5.1: sodium azide / N,N-dimethyl-formamide / 1.5 h / 20 °C
6.1: hydrogen / palladium on activated carbon / methanol / 0.5 h
7.1: 6-chloro-7H-purine / ethanol / 22 h / 100 °C
With
sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; sodium carbonate; 6-chloro-7H-purine; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0); palladium on activated carbon;
In
tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile; cyclohexene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C
2: thionyl chloride / chloroform / 3 h / 20 °C
3: sodium azide / N,N-dimethyl-formamide / 1.5 h / 20 °C
4: hydrogen / palladium on activated carbon / methanol / 0.5 h
5: 6-chloro-7H-purine / ethanol / 22 h / 100 °C
With
sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; 6-chloro-7H-purine;
palladium on activated carbon;
In
tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;
