(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

Base Information

Chemical Name:(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine
CAS No.:1065481-69-7
Molecular Formula:C₁₇H₁₁ClF₄N₂
Molecular Weight:354.734
Hs Code.:

Synonyms:(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

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Chemical Property of (8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

Chemical Property:

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Technology Process of (8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

There total 6 articles about (8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

: 1065481-70-0
3-(azidomethyl)-8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline

: 1065481-69-7
(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

Guidance literature:: With hydrogen; palladium on activated carbon; In methanol; for 0.5h;

Reference yield:

: 4470-83-1
2,8-dichloroquinoline

: 1065481-69-7
(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexene / 2 h / -78 °C

1.2: 4 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 14 h / 100 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

4.1: thionyl chloride / chloroform / 3 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 1.5 h / 20 °C

6.1: hydrogen / palladium on activated carbon / methanol / 0.5 h

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; sodium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated carbon; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile; cyclohexene;

Reference yield:

: 1065481-66-4
8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline-3-carbaldehyde

: 1065481-69-7
(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

2: thionyl chloride / chloroform / 3 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: hydrogen / palladium on activated carbon / methanol / 0.5 h

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; palladium on activated carbon; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;