7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

Base Information

Chemical Name:7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid
CAS No.:868836-45-7
Molecular Formula:C₂₆H₄₄N₄O₅
Molecular Weight:492.659
Hs Code.:

Synonyms:7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

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Chemical Property of 7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

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Technology Process of 7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

There total 6 articles about 7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

: 913174-01-3
7-{{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}}heptanoic acid

: 868836-45-7
7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

Guidance literature:: 7-{{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}}heptanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm0505009

Reference yield: 74.4%

: 868836-45-7
7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

Guidance literature:

Reference yield:

: 868835-87-4
N-{4-[(N,N-dimethylamino)benzyl]butyl}phthalimide

: 868836-45-7
7-{4-[N-(tert-butyloxycarbonyl)amino]butyl}-{N-[4-N,N-(dimethyl)aminobenzyl]carbamoyl}heptanohydroxamic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72.6 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: hydrazine / methanol / 12 h / Heating

3.1: 70.2 percent / aq. NaHCO₃; NaCl / CH₂Cl₂ / 0 - 20 °C

4.1: aq. LiOH / tetrahydrofuran / 0 - 20 °C

5.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / 0 °C

5.2: 74.4 percent / hydroxylamine / methanol; tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; sodium chloride; hydrazine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0505009