7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
• CAS No.: 1460737-82-9
• Molecular Formula: C₃₀H₃₂FN₅O₆
• Molecular Weight: 577.612
• Mol file: 1460737-82-9.mol

Synonyms:7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Chemical Property of 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

There total 2 articles about 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

bis(trichloromethyl) carbonate (32315-10-9) + phenylmethyl 1-piperazinecarboxylate (31166-44-6) + ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-82-9)

Guidance literature:

bis(trichloromethyl) carbonate; phenylmethyl 1-piperazinecarboxylate; In dichloromethane; for 1h;

ciprofloxacin; With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; at 20 ℃; for 2h;

DOI:10.3390/molecules18077557

Reference yield:

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (86393-33-1,178489-04-8) → 7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 2 h / Microwave irradiation

2.1: dichloromethane / 1 h

2.2: 2 h / 20 °C

In dichloromethane; dimethyl sulfoxide;

DOI:10.3390/molecules18077557

Reference yield:

7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-82-9) → 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / dichloromethane; ethanol / 1 h / 20 °C / 760.05 Torr

2: triethylamine / dichloromethane; ethanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; dichloromethane;

DOI:10.3390/molecules18077557

upstream raw materials:

bis(trichloromethyl) carbonate

phenylmethyl 1-piperazinecarboxylate

ciprofloxacin

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

Downstream raw materials:

1-cyclopropyl-7-(4-[4-(2,4-dimethoxybenzoyl)piperazino]carbopiperazino)-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

7-(4-[4-(4-chlorobenzenesulfonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

1-cyclopropyl-6-fluoro-4-oxo-7-(4-[4-(4-trifluoromethoxybenzenesulfonyl)piperazino]carbopiperazino)-1,4-dihydro-3-quinolinecarboxylic acid