1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
• CAS No.: 1460737-92-1
• Molecular Formula: C₂₈H₂₉F₂N₅O₆S
• Molecular Weight: 601.631
• Mol file: 1460737-92-1.mol

Synonyms:1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Chemical Property of 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

There total 4 articles about 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 1-cyclopropyl-6-fluoro-4-oxo-7-[4-(piperazin-1-yl)carbopiperazino]-1,4-dihydro-3-quinolinecarboxylic acid (1460737-83-0) → 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-92-1)

Guidance literature:

With triethylamine; In ethanol; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.3390/molecules18077557

Reference yield:

ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h

1.2: 2 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / dichloromethane; ethanol / 1 h / 20 °C / 760.05 Torr

3.1: triethylamine / dichloromethane; ethanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; dichloromethane;

DOI:10.3390/molecules18077557

Reference yield:

7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-82-9) → 1-cyclopropyl-6-fluoro-7-(4-[4-(4-fluorobenzenesulfonyl)piperazino]carbopiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1460737-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / dichloromethane; ethanol / 1 h / 20 °C / 760.05 Torr

2: triethylamine / dichloromethane; ethanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; dichloromethane;

DOI:10.3390/molecules18077557

upstream raw materials:

7-(4-[4-(benzyloxycarbonyl)piperazino]carbopiperazino)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

ciprofloxacin

4-Fluorobenzenesulfonyl chloride

1-cyclopropyl-6-fluoro-4-oxo-7-[4-(piperazin-1-yl)carbopiperazino]-1,4-dihydro-3-quinolinecarboxylic acid