(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Base Information

Chemical Name:(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide
CAS No.:174649-05-9
Molecular Formula:C₃₀H₂₇FN₄O₆
Molecular Weight:558.566
Hs Code.:

Synonyms:(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

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Chemical Property of (S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

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Technology Process of (S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

There total 4 articles about (S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1281885-30-0
(R)-benzyl 4-(2-fluoro-4-(2-oxo-5-(tosyloxymethyl)oxazolidin-3-yl)phenyl)piperazine-1-carboxylate

: 1074-82-4
potassium phtalimide

: 174649-05-9
(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Guidance literature:: In lithium hydroxide monohydrate; acetonitrile; Reflux;

Reference yield:

: 1074-82-4
potassium phtalimide

: 903594-02-5
4-[2-Fluoro-4-((R)-5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-phenyl]-piperazine-1-carboxylic acid benzyl ester

: 174649-05-9
(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Guidance literature:: In water; acetonitrile; for 48h; Yield given; Heating;
DOI:10.1021/jm9509556

Reference yield:

: 154590-33-7
1-(2-fluoro-4-nitrophenyl)piperazine

: 174649-05-9
(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / Inert atmosphere

2: sodium carbonate / water; acetone

3: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

4: triethylamine / dichloromethane / Inert atmosphere

5: water; acetonitrile / Inert atmosphere; Reflux

With n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.bmc.2014.05.054