(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Base Information

Chemical Name:(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CAS No.:1622399-53-4
Molecular Formula:C₂₂H₃₀FN₇O₄
Molecular Weight:475.523
Hs Code.:

Synonyms:(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Chemical Property of (S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Technology Process of (S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

There total 11 articles about (S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1622399-51-2
(S)-N-((3-(4-(4-(3-azidopropyl)piperazin-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

: 107-19-7
propargyl alcohol

: 1622399-53-4
(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water; for 16h;
DOI:10.1016/j.bmc.2014.05.054

Reference yield:

: 174649-05-9
(S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

: 1622399-53-4
(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: methylamine / water; ethanol / Reflux

2: pyridine / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / Inert atmosphere

4: triethylamine; sodium iodide / ethanol / 6 h / Reflux; Inert atmosphere

5: copper(II) sulfate; sodium L-ascorbate / water; methanol / 16 h

With pyridine; palladium 10% on activated carbon; hydrogen; copper(II) sulfate; sodium L-ascorbate; triethylamine; methylamine; sodium iodide; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2014.05.054

Reference yield:

: 174649-06-0
(S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

: 1622399-53-4
(S)-N-((3-(3-fluoro-4-(4-(3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)propyl)piper-azin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / Inert atmosphere

2: triethylamine; sodium iodide / ethanol / 6 h / Reflux; Inert atmosphere

3: copper(II) sulfate; sodium L-ascorbate / water; methanol / 16 h

With palladium 10% on activated carbon; hydrogen; copper(II) sulfate; sodium L-ascorbate; triethylamine; sodium iodide; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2014.05.054