N-heptanoyl-4-chlorobenzamide

Base Information

• Chemical Name: N-heptanoyl-4-chlorobenzamide
• CAS No.: 39549-66-1
• Molecular Formula: C₁₄H₁₈ClNO₂
• Molecular Weight: 267.755
• Mol file: 39549-66-1.mol

Synonyms:N-heptanoyl-4-chlorobenzamide

Chemical Property of N-heptanoyl-4-chlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-heptanoyl-4-chlorobenzamide

There total 1 articles about N-heptanoyl-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

n-heptanoic anhydride (626-27-7) + 4-chlorobenzamide (619-56-7) → N-heptanoyl-4-chlorobenzamide (39549-66-1)

Guidance literature:

With sulfuric acid; at 100 ℃; for 0.05h; Microwave irradiation;

DOI:10.1016/j.tet.2012.01.003

Reference yield: 50.0%

N-heptanoyl-4-chlorobenzamide (39549-66-1) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → LH-21 (611207-11-5)

Guidance literature:

With pyridine; at 200 ℃; for 0.0166667h; regioselective reaction; Microwave irradiation;

DOI:10.1016/j.tet.2012.01.003

Reference yield: 12.0%

N-heptanoyl-4-chlorobenzamide (39549-66-1) + N-4-chlorophenylhydrazine (1073-69-4) → 1,5-bis-(4-chloro-phenyl)-3-hexyl-1H-[1,2,4]triazole

Guidance literature:

With sodium acetate; In acetic acid; for 22h; Heating;

DOI:10.1021/jm031099y

upstream raw materials:

n-heptanoic anhydride

4-chlorobenzamide

Downstream raw materials:

LH-21

Refernces

• 1、 Jagerovic, Nadine,Hernandez-Folgado, Laura,Alkorta, Ibon,Goya, Pilar,Navarro, Miguel,Serrano, Antonia,Rodriguez De Fonseca, Fernando,Dannert, M. Teresa,Alsasua, Angela,Suardiaz, Margarita,Pascual, David,Martín, Maria Isabel. "Discovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif". . p. 2939 - 2942. Retrieved 2007/10/03.