2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester

Base Information

• Chemical Name: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester
• CAS No.: 942948-65-4
• Molecular Formula: C₂₄H₂₀O₅
• Molecular Weight: 388.42
• Mol file: 942948-65-4.mol

Synonyms:2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester

Chemical Property of 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester

There total 1 articles about 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.8%

fluorescein free acid (518-45-6) + tert-butyl alcohol (75-65-0) → 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester (942948-65-4)

Guidance literature:

With 4 A molecular sieve; sulfuric acid; at 120 ℃; for 14h;

DOI:10.1021/ja070376d

Reference yield: 57.0%

2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester (942948-65-4) + 2-nitrophenylmethyl bromide (3958-60-9) → 2-[6-(2-nitrobenzyloxy)-3-oxo-3H-xanthen-9-yl]benzoic acid tert-butyl ester

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 26h;

DOI:10.1021/ja070376d

Reference yield:

2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid tert-butyl ester (942948-65-4) → 2-[6-(2-nitrobenzyloxy)-3-oxo-3H-xanthen-9-yl]benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / Cs₂CO₃ / dimethylformamide / 26 h / 20 °C

2: 32 percent / TFA / CH₂Cl₂ / 3.5 h / 20 °C

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja070376d

upstream raw materials:

fluorescein free acid

tert-butyl alcohol