(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Base Information

Chemical Name:(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide
CAS No.:266694-24-0
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Suppliers and Price of (3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

There total 10 articles about (3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid 1-((4S,5R)-4-tert-butoxycarbonylamino-2-oxo-5-phenyl-tetrahydro-furan-3-yl)-3-phenyl-propyl ester

: 266694-24-0
(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 10 ℃;
DOI:10.1021/jo991241w

Reference yield:

: 266694-08-0
(S)-2-benzyloxycarbonylamino-4-tert-butyldimethylsilyloxy-1-phenylbutan-1-one

: 266694-24-0
(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pd/C / ethanol / 10 h / 25 °C / 2660.18 Torr

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 157 mg / aq. HCl / methanol; dioxane / 25 °C

4: RuCl₂*xH₂O; NaIO₄ / acetonitrile; H₂O; CCl₄ / 1.5 h / 25 °C

5: 194 mg / SOCl₂ / 17 h / 25 °C

6: Et₃N; DMAP / tetrahydrofuran / 17 h / 25 °C

7: 7.51 g / Cs₂CO₃ / methanol / 17 h / 25 °C

8: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

9: Et₃N / CH₂Cl₂ / 1 h / 0 °C

10: DBU / tetrahydrofuran / 10 °C

With ruthenium(II) chloride; hydrogenchloride; dmap; sodium periodate; thionyl chloride; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; hexane; dichloromethane; water; acetonitrile; 1: Hydrogenolysis / 2: Cyclization / 3: Hydrolysis / 4: Oxidation / 5: Esterification / 6: Substitution / 7: Hydrolysis / 8: Addition / 9: Condensation / 10: Elimination;
DOI:10.1021/jo991241w

Reference yield:

: 177839-63-3
(4S,5R)-4-hydroxyethyl-5-phenyloxazolidin-2-one

: 266694-24-0
(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

Guidance literature:: Multi-step reaction with 7 steps

1: RuCl₂*xH₂O; NaIO₄ / acetonitrile; H₂O; CCl₄ / 1.5 h / 25 °C

2: 194 mg / SOCl₂ / 17 h / 25 °C

3: Et₃N; DMAP / tetrahydrofuran / 17 h / 25 °C

4: 7.51 g / Cs₂CO₃ / methanol / 17 h / 25 °C

5: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

6: Et₃N / CH₂Cl₂ / 1 h / 0 °C

7: DBU / tetrahydrofuran / 10 °C

With ruthenium(II) chloride; dmap; sodium periodate; thionyl chloride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; acetonitrile; 1: Oxidation / 2: Esterification / 3: Substitution / 4: Hydrolysis / 5: Addition / 6: Condensation / 7: Elimination;
DOI:10.1021/jo991241w