[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

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Chemical Name:[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester
CAS No.:266694-07-9
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

There total 11 articles about [(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 266694-24-0
(3S,4R)-3-tert-butoxycarbonylamino-4-phenyl-2-(phenylpropylidene)-4-butanolide

: 266694-07-9
[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

: [(2R,3S,4R)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol; at 0 ℃; for 0.166667h;
DOI:10.1021/jo991241w

Reference yield:

: 266694-08-0
(S)-2-benzyloxycarbonylamino-4-tert-butyldimethylsilyloxy-1-phenylbutan-1-one

: 266694-07-9
[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: H₂ / Pd/C / ethanol / 10 h / 25 °C / 2660.18 Torr

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 157 mg / aq. HCl / methanol; dioxane / 25 °C

4: RuCl₂*xH₂O; NaIO₄ / acetonitrile; H₂O; CCl₄ / 1.5 h / 25 °C

5: 194 mg / SOCl₂ / 17 h / 25 °C

6: Et₃N; DMAP / tetrahydrofuran / 17 h / 25 °C

7: 7.51 g / Cs₂CO₃ / methanol / 17 h / 25 °C

8: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

9: Et₃N / CH₂Cl₂ / 1 h / 0 °C

10: DBU / tetrahydrofuran / 10 °C

11: 64 percent / NiCl₂*6H₂O; NaBH₄ / tetrahydrofuran; methanol / 0.17 h / 0 °C

With ruthenium(II) chloride; hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; thionyl chloride; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; nickel dichloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; hexane; dichloromethane; water; acetonitrile; 1: Hydrogenolysis / 2: Cyclization / 3: Hydrolysis / 4: Oxidation / 5: Esterification / 6: Substitution / 7: Hydrolysis / 8: Addition / 9: Condensation / 10: Elimination / 11: Reduction;
DOI:10.1021/jo991241w

Reference yield:

: 177839-63-3
(4S,5R)-4-hydroxyethyl-5-phenyloxazolidin-2-one

: 266694-07-9
[(2R,3S,4S)-5-Oxo-2-phenyl-4-(3-phenyl-propyl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: RuCl₂*xH₂O; NaIO₄ / acetonitrile; H₂O; CCl₄ / 1.5 h / 25 °C

2: 194 mg / SOCl₂ / 17 h / 25 °C

3: Et₃N; DMAP / tetrahydrofuran / 17 h / 25 °C

4: 7.51 g / Cs₂CO₃ / methanol / 17 h / 25 °C

5: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

6: Et₃N / CH₂Cl₂ / 1 h / 0 °C

7: DBU / tetrahydrofuran / 10 °C

8: 64 percent / NiCl₂*6H₂O; NaBH₄ / tetrahydrofuran; methanol / 0.17 h / 0 °C

With ruthenium(II) chloride; dmap; sodium tetrahydroborate; sodium periodate; thionyl chloride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; nickel dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; acetonitrile; 1: Oxidation / 2: Esterification / 3: Substitution / 4: Hydrolysis / 5: Addition / 6: Condensation / 7: Elimination / 8: Reduction;
DOI:10.1021/jo991241w