Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Base Information

• Chemical Name: Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester
• CAS No.: 228873-47-0
• Molecular Formula: C₃₃H₃₅NO₁₀
• Molecular Weight: 605.642
• Mol file: 228873-47-0.mol

Synonyms:Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Chemical Property of Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

There total 1 articles about Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,3,4-tri-O-benzyl-D-glucopyranoside (53008-65-4,641635-63-4) + di(succinimido) carbonate (74124-79-1) → Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester (228873-47-0)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/S0040-4039(99)00843-6

Reference yield: 88.0%

2,3,4,6-tetra-O-benzoyl-D-glucopyranose (627466-64-2) + Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester (228873-47-0) → C63H58O17

Guidance literature:

With potassium carbonate; In toluene; at 20 ℃; for 26h;

DOI:10.1016/S0040-4039(99)00843-6

Reference yield:

guanfacine hydrochloride (29110-48-3,29520-14-7) + Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester (228873-47-0) → C38H39Cl2N3O8

Guidance literature:

With 4-methyl-morpholine;

upstream raw materials:

methyl 2,3,4-tri-O-benzyl-D-glucopyranoside

di(succinimido) carbonate

Downstream raw materials:

2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6S)-3,5-bis-(2,2-dimethyl-propionyloxy)-2-(2,2-dimethyl-propionyloxymethyl)-6-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxycarbonyloxy)-tetrahydro-pyran-4-yl ester

2-(2,6-dichlorophenyl)-N-(N-((((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)carbonyl)carbamimidoyl)acetamide hydrochloride