E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

Base Information

Chemical Name:E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid
CAS No.:690633-28-4
Molecular Formula:C₁₆H₁₆N₂O₄
Molecular Weight:300.314
Hs Code.:

Synonyms:E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

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Chemical Property of E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

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Technology Process of E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

There total 5 articles about E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 673486-72-1
1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazine-3-carbaldehyde

: 690633-28-4
E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2003.12.093

Reference yield:

: 89532-94-5
methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

: 690633-28-4
E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / NaH / dimethylformamide / 0 - 20 °C

2: 58 percent / NaBH₄ / tetrahydrofuran; methanol / Heating

3: 30 percent / MnO₂ / toluene / Heating

4: 42 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 4: Wittig reaction;
DOI:10.1081/NCN-120022958

Reference yield:

: 13192-04-6
dimethyl 2-ketoglutarate

: 690633-28-4
E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NH₂NH₂; acetic acid / methanol / Heating

2: 84 percent / NaH / dimethylformamide / 0 - 20 °C

3: 58 percent / NaBH₄ / tetrahydrofuran; methanol / Heating

4: 30 percent / MnO₂ / toluene / Heating

5: 42 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium hydride; acetic acid; hydrazine; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 5: Wittig reaction;
DOI:10.1081/NCN-120022958