2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide

Base Information

Chemical Name:2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide
CAS No.:910297-59-5
Molecular Formula:C₁₈H₂₀ClN₇OS
Molecular Weight:417.922
Hs Code.:
UNII:KX8EP6R6SN

Synonyms:2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide;910297-59-5;KX8EP6R6SN;SCHEMBL1147077;5-Thiazolecarboxamide, 2-[[6-[(2-aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-

Suppliers and Price of 2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:417.1138572
Heavy Atom Count:28
Complexity:516

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)NCCN)C

Technology Process of 2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide

There total 4 articles about 2-[[6-[(2-Aminoethyl)amino]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

: 107-15-3,85404-18-8
ethylenediamine

: 302964-08-5
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

: 910297-59-5
2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Guidance literature:: In 1,4-dioxane; for 90h; Inert atmosphere;
DOI:10.1021/ja208518u

Reference yield:

: 40398-01-4
2-chloro-6-methylphenyl isocyanate

: 910297-59-5
2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / Reflux; Inert atmosphere

4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere

5.1: 1,4-dioxane / 90 h / Inert atmosphere

With n-butyllithium; trifluorormethanesulfonic acid; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetone;
DOI:10.1021/ja208518u

Reference yield:

: 302964-11-0
2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

: 910297-59-5
2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetone / 10 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / Reflux; Inert atmosphere

3.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 9 h / 20 °C / Inert atmosphere

4.1: 1,4-dioxane / 90 h / Inert atmosphere

With trifluorormethanesulfonic acid; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/ja208518u