Technology Process of 1-(benzyloxy)-5-bromo-2-methoxy-4-vinylbenzene
There total 1 articles about 1-(benzyloxy)-5-bromo-2-methoxy-4-vinylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-triphenylphosphonium iodide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
4-benzyloxy-6-bromo-3-methoxybenzaldehyde;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ol303390a
- Guidance literature:
-
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); water;
In
1,4-dioxane;
at 80 ℃;
for 40h;
Inert atmosphere;
DOI:10.1021/ol303390a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: water; potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 40 h / 80 °C / Inert atmosphere
2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 22 h / 50 °C / Inert atmosphere
3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 24 h / 31029.7 Torr / Inert atmosphere
4: pyridine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
5: water; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide / 1,4-dioxane / 36 h / 80 °C / Inert atmosphere
With
pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 5%-palladium/activated carbon; water; hydrogen; potassium bromide;
In
1,4-dioxane; dichloromethane; ethyl acetate;
1: |Suzuki Coupling / 2: |Diels-Alder Cycloaddition;
DOI:10.1021/ol303390a
