Technology Process of 5'-(benzyloxy)-2-isopropoxy-3,4'-dimethoxy-2',6-divinyl-1,1'-biphenyl
There total 5 articles about 5'-(benzyloxy)-2-isopropoxy-3,4'-dimethoxy-2',6-divinyl-1,1'-biphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); water;
In
1,4-dioxane;
at 80 ℃;
for 40h;
Inert atmosphere;
DOI:10.1021/ol303390a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 8 h / 20 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C / Inert atmosphere
3.1: water; potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 40 h / 80 °C / Inert atmosphere
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); water; tert.-butyl lithium; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane; hexane; mineral oil;
1.2: |Wittig Olefination / 3.1: |Suzuki Coupling;
DOI:10.1021/ol303390a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
2.2: 8 h / 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
4.1: water; potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 40 h / 80 °C / Inert atmosphere
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); water; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide; mineral oil;
2.2: |Wittig Olefination / 4.1: |Suzuki Coupling;
DOI:10.1021/ol303390a
