1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

Base Information

Chemical Name:1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide
CAS No.:1618699-45-8
Molecular Formula:C₂₃H₂₃N₅O
Molecular Weight:385.469
Hs Code.:

Synonyms:1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

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Chemical Property of 1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

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Technology Process of 1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

There total 5 articles about 1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1618648-12-6
[4-({[1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carbonyl]amino}methyl)benzyl]carbamic acid tert-butyl ester

: 1618699-45-8
1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 108468-00-4
tert-butyl 4-(aminomethyl)benzylcarbamate

: 1618699-45-8
1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; triethylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

3: water; hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 635-80-3
quinaldine-6-carboxylic acid

: 1618699-45-8
1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: phosphorus tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

4.1: water; hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; phosphorus tribromide; caesium carbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;