3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

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Chemical Name:3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile
CAS No.:1197342-15-6
Molecular Formula:C₃₁H₃₀N₈O
Molecular Weight:530.632
Hs Code.:

Synonyms:3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

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Chemical Property of 3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

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Technology Process of 3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

There total 9 articles about 3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000802-52-7
1-[2-(pyrrolidin-1-yl)ethyl]-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 3-(1-{2-[3-(5-bromopyrimidin-2-yl)phenyl]acetyl}-4,5-dihydro-1H-pyrazol-3-yl)benzonitrile

: 1197342-15-6
3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: With potassium phosphate tribasic trihydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 80 ℃; for 42h; Inert atmosphere;

Reference yield:

: 6136-68-1
3-acethylbenzonitrile

: 1197342-15-6
3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

1.2: pH 9

2.1: tetrahydrofuran / 48 h / 20 °C

3.1: hydrazine hydrate / 1 h / 50 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

5.1: potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

6.1: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 42 h / 80 °C / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; potassium phosphate tribasic trihydrate; potassium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1197342-24-7
3-(3-dimethylaminopropionyl)benzonitrile

: 1197342-15-6
3-{1-[2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}phenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 48 h / 20 °C

2.1: hydrazine hydrate / 1 h / 50 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

4.1: potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

5.1: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 42 h / 80 °C / Inert atmosphere

With hydrazine hydrate; potassium phosphate tribasic trihydrate; potassium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;