trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

Base Information

Chemical Name:trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol
CAS No.:1032452-76-8
Molecular Formula:C₂₅H₂₆N₄OS
Molecular Weight:430.574
Hs Code.:

Synonyms:trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

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Chemical Property of trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

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Technology Process of trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

There total 2 articles about trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1032452-75-7
4-benzylsulfanyl-1-(2-chloro-pyrimidin-4-yl)-1H-indole

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 1032452-76-8
trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 4h;

Reference yield:

: 92554-48-8
4-benzylthioindole

: 1032452-76-8
trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 4 h / 110 °C

With sodium hydride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield: 7.0%

: 1032452-76-8
trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol

: 1032452-77-9
trans-4-[4-(4-Phenylmethanesulfonylindol-1-yl)-pyrimidin-2-yl-amino]-cyclohexanol

Guidance literature:: trans-4-[4-(4-benzylsulfanylindol-1-yl)-pyrimidin-2-ylamino]-cyclo-hexanol; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃;

With sodium hydrogencarbonate; In chloroform; water;