methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

Base Information

Chemical Name:methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate
CAS No.:873696-93-6
Molecular Formula:C₃₀H₃₀N₂O₅
Molecular Weight:498.579
Hs Code.:

Synonyms:methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

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Chemical Property of methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

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Technology Process of methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

There total 9 articles about methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 873696-85-6
5-[3-(7-propyl-3-phenylbenzo[d]isoxazol-6-yloxy)propoxy]-1H-indole

: 96-32-2
bromoacetic acid methyl ester

: 873696-93-6
methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 12h; Heating;
DOI:10.1021/jm0506930

Reference yield:

: 131-56-6
2.4-dihydroxybenzophenone

: 873696-93-6
methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: K₂CO₃; KI / acetone / 4 h / Heating

2.1: 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation

3.1: H₂ / Pd/C / ethyl acetate / 2 h / 2280 Torr

4.1: NH₂OH*HCl; pyridine / 24 h / Heating

5.1: Ac₂O; NaOAc / dimethylformamide / 6 h / Heating

5.2: aq. NaOH / 2.5 h / 60 °C

6.1: 84 percent / K₂CO₃; KI / dimethylformamide / 2 h / 110 °C

7.1: 78 percent / K₂CO₃; KI / acetonitrile / 12 h / Heating

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; potassium iodide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; acetonitrile;
DOI:10.1021/jm0506930

Reference yield:

: 2549-87-3
2-hydroxy-4-prop-2-enyloxybenzophenone

: 873696-93-6
methyl 2-{5-[3-(3-phenyl-7-propylbenzo[b]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation

2.1: H₂ / Pd/C / ethyl acetate / 2 h / 2280 Torr

3.1: NH₂OH*HCl; pyridine / 24 h / Heating

4.1: Ac₂O; NaOAc / dimethylformamide / 6 h / Heating

4.2: aq. NaOH / 2.5 h / 60 °C

5.1: 84 percent / K₂CO₃; KI / dimethylformamide / 2 h / 110 °C

6.1: 78 percent / K₂CO₃; KI / acetonitrile / 12 h / Heating

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; potassium iodide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile;
DOI:10.1021/jm0506930