Technology Process of 5-[3-(7-propyl-3-phenylbenzo[d]isoxazol-6-yloxy)propoxy]-1H-indole
There total 7 articles about 5-[3-(7-propyl-3-phenylbenzo[d]isoxazol-6-yloxy)propoxy]-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate; potassium iodide;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 2h;
DOI:10.1021/jm0506930
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: K2CO3; KI / acetone / 4 h / Heating
2.1: 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation
3.1: H2 / Pd/C / ethyl acetate / 2 h / 2280 Torr
4.1: NH2OH*HCl; pyridine / 24 h / Heating
5.1: Ac2O; NaOAc / dimethylformamide / 6 h / Heating
5.2: aq. NaOH / 2.5 h / 60 °C
6.1: 84 percent / K2CO3; KI / dimethylformamide / 2 h / 110 °C
With
pyridine; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; potassium iodide;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone;
DOI:10.1021/jm0506930
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1,2-dichloro-benzene / 0.25 h / 250 °C / microwave irradiation
2.1: H2 / Pd/C / ethyl acetate / 2 h / 2280 Torr
3.1: NH2OH*HCl; pyridine / 24 h / Heating
4.1: Ac2O; NaOAc / dimethylformamide / 6 h / Heating
4.2: aq. NaOH / 2.5 h / 60 °C
5.1: 84 percent / K2CO3; KI / dimethylformamide / 2 h / 110 °C
With
pyridine; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; potassium iodide;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/jm0506930