N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

Base Information

Chemical Name:N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine
CAS No.:685886-09-3
Molecular Formula:C₂₂H₂₇N₃O₃
Molecular Weight:381.475
Hs Code.:

Synonyms:N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

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Chemical Property of N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

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Technology Process of N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

There total 12 articles about N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylcarbamate

: 685886-09-3
N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

Guidance literature:: tert-butyl N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylcarbamate; With hydrogenchloride; In ethyl acetate; at 40 ℃; for 1h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 685886-67-3
[2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid

: 685886-09-3
N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: barium dihydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C

2: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 40 °C

3: hydrogenchloride / ethyl acetate / 1 h / 40 °C

With hydrogenchloride; barium dihydroxide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; water; ethyl acetate;

Reference yield:

: 685886-51-5
7-bromo-2-methylpyrazolo[1,5-a]pyridine

: 685886-09-3
N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-methylpyrazolo[1,5-a]pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: nitronium tetrafluoborate / acetonitrile / 0.17 h / 0 °C

2: acetic acid; zinc / ethanol; water / 0.5 h / 20 - 60 °C

3: triethylamine / dichloromethane / 15 h / 0 - 20 °C

4: barium dihydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C

5: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 40 °C

6: hydrogenchloride / ethyl acetate / 1 h / 40 °C

With hydrogenchloride; barium dihydroxide; nitronium tetrafluoborate; sodium hydride; acetic acid; triethylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;