(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

Base Information

Chemical Name:(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide
CAS No.:878551-33-8
Molecular Formula:C₄₂H₆₁NO₄Si₂
Molecular Weight:700.122
Hs Code.:

Synonyms:(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

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Chemical Property of (+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

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Technology Process of (+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

There total 8 articles about (+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 866021-06-9
(+/-)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxylic acid

: 123-30-8
4-amino-phenol

: 878551-33-8
(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

Guidance literature:: (+/-)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxylic acid; With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; at 0 - 25 ℃; for 1.33333h;

4-amino-phenol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 17h;
DOI:10.1021/jm050226i

Reference yield:

: 769073-61-2
2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

: 878551-33-8
(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 11.553 g / 5 h / 60 - 100 °C

2.1: NaH / tetrahydrofuran; hexane / 3 h / 25 °C

2.2: 100 percent / tetrahydrofuran; hexane / 14 h / 25 °C

3.1: 55 percent / BBr₃ / CH₂Cl₂ / 7.5 h / -78 - 25 °C

4.1: 81 percent / imidazole / dimethylformamide / 3.5 h / 25 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 - 10 °C

5.2: 78 percent / tetrahydrofuran; hexane

6.1: HBTU; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.33 h / 0 - 25 °C

6.2: 39 percent / diisopropylethylamine / CH₂Cl₂ / 17 h / 25 °C

With 1H-imidazole; dmap; n-butyllithium; boron tribromide; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050226i

Reference yield:

: 866021-04-7
1-(3-methoxyphenyl)-2-(4-methoxyphenyl)pentan-3-one

: 878551-33-8
(+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 55 percent / BBr₃ / CH₂Cl₂ / 7.5 h / -78 - 25 °C

2.1: 81 percent / imidazole / dimethylformamide / 3.5 h / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 - 10 °C

3.2: 78 percent / tetrahydrofuran; hexane

4.1: HBTU; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.33 h / 0 - 25 °C

4.2: 39 percent / diisopropylethylamine / CH₂Cl₂ / 17 h / 25 °C

With 1H-imidazole; dmap; n-butyllithium; boron tribromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050226i