2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

Base Information

Chemical Name:2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid
CAS No.:769073-61-2
Molecular Formula:C₁₂H₁₄O₄
Molecular Weight:222.241
Hs Code.:2918990090
DSSTox Substance ID:DTXSID00513680
Mol file:769073-61-2.mol

Synonyms:769073-61-2;2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid;SCHEMBL9355324;DTXSID00513680

Suppliers and Price of 2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

Chemical Property:

PSA：59.06000
LogP:1.99990
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:222.08920892
Heavy Atom Count:16
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C(O1)C2=CC=C(C=C2)OC)C(=O)O

Technology Process of 2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

There total 2 articles about 2-Ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109368-12-9
ethyl 2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylate

: 769073-61-2
2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Heating;
DOI:10.1021/jm050226i

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 769073-61-2
2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyl-disilazide / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 2 h / -78 - 25 °C

2.1: aq. NaOH / ethanol / 4 h / Heating

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1021/jm050226i

Reference yield:

: 769073-61-2
2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

: 866021-05-8
1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 11.553 g / 5 h / 60 - 100 °C

2.1: NaH / tetrahydrofuran; hexane / 3 h / 25 °C

2.2: 100 percent / tetrahydrofuran; hexane / 14 h / 25 °C

3.1: 55 percent / BBr₃ / CH₂Cl₂ / 7.5 h / -78 - 25 °C

4.1: 81 percent / imidazole / dimethylformamide / 3.5 h / 25 °C

With 1H-imidazole; boron tribromide; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050226i