L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI)

Base Information

• Chemical Name: L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI)
• CAS No.: 141171-80-4
• Molecular Formula: C₃₃H₄₀N₆O₆
• Molecular Weight: 616.717
• Mol file: 141171-80-4.mol

Synonyms:L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(2S,3S)-2-hydroxy-4-phenyl-3-aminobutanoyl-N-(1,1-dimethylethyl)-;KNI 153; Ro 32-1636

Chemical Property of L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI)

Chemical Property:

• PSA: 183.82000
• LogP: 3.01360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI)

There total 1 articles about L-Prolinamide,N2-(2-quinolinylcarbonyl)-L-asparaginyl-(aS,bS)-b-amino-a-hydroxybenzenebutanoyl-N-(1,1-dimethylethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-N-tert-butyl-1-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carboxamide (153380-43-9) + (2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid (136465-98-0) → 1-<(2S,3S)-2-hydroxy-3-2-(2-quinolylcarbonyl)-L-asparaginyl>amino-2-hydroxy-4-phenylbutyryl>-N-tert-butyl-L-prolinamide (141171-80-4)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; a) -5 deg C, 1 h, b) RT, 19 h;

DOI:10.1248/cpb.42.2636

Reference yield:

1-<(2S,3S)-2-hydroxy-3-2-(2-quinolylcarbonyl)-L-asparaginyl>amino-2-hydroxy-4-phenylbutyryl>-N-tert-butyl-L-prolinamide (141171-80-4) → 1-<(3S)-2-oxo-3-2-(2-quinolylcarbonyl)-L-asparaginyl>amino-2-hydroxy-4-phenylbutyryl>-N-tert-butyl-L-prolinamide

Guidance literature:

With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; for 22h; Ambient temperature;

DOI:10.1248/cpb.42.2636

upstream raw materials:

(S)-N-tert-butyl-1-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carboxamide

(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid