136465-98-0

Usage

Uses

Used in Biochemical Research:
N-(2-quinolylcarbonyl)-L-asparagine is used as a fluorescent probe for tagging and studying proteins and other biomolecules. Its application is crucial in understanding protein-protein interactions and enzyme activities, which are fundamental to various biological processes.
Used in Assays for Protein-Protein Interactions:
In the field of molecular biology, QA-L-Asn is used as a tool in assays designed to investigate the interactions between proteins. Its binding properties allow researchers to monitor and analyze these interactions, contributing to a deeper understanding of cellular mechanisms.
Used in Enzyme Activity Studies:
N-(2-quinolylcarbonyl)-L-asparagine is employed in assays to study enzyme activities. By tagging enzymes with QA-L-Asn, researchers can track and measure the activity of these enzymes, which is essential for elucidating their roles in metabolic pathways and other biological functions.
Used in Drug Development:
Due to its ability to modulate protein function and activity, QA-L-Asn is being studied for its potential therapeutic applications. Its use in drug development could lead to the creation of new treatments that target specific proteins involved in diseases.
Used in Medicine:
The potential of QA-L-Asn to influence protein function suggests its utility in the medical field. It may be developed into a therapeutic agent that could be used to treat conditions related to protein misregulation or dysfunction.

InChI:InChI=1/C14H13N3O4/c15-12(18)7-11(14(20)21)17-13(19)10-6-5-8-3-1-2-4-9(8)16-10/h1-6,11H,7H2,(H2,15,18)(H,17,19)(H,20,21)/t11-/m0/s1

Upstream product

• 70-47-3 L-asparagine 
• 136465-99-1 2,5-dioxopyrrolidin-1-ylquinoline-2-carboxylate 
• 93-10-7 quinoline-2-carboxylic acid 
• 161836-75-5 quinoline-2-carbonyl-(L)-asparagine tert-butyl ester 

Downstream Products

• 141171-80-4 1-<(2S,3S)-2-hydroxy-3-2-(2-quinolylcarbonyl)-L-asparaginyl>amino-2-hydroxy-4-phenylbutyryl>-N-tert-butyl-L-prolinamide 
• 127779-20-8 Saquinavir 
• 197067-77-9 (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole 
• 197067-87-1 (S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester 
• 417704-45-1 (2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole 
• 137622-85-6 C₃₈H₅₀N₆O₅ 
• 1217649-53-0 (S)-N₁-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(4-phenylthiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamide 
• 161723-77-9 C₃₀H₂₈N₄O₄ 

Relevant academic research and scientific papers

Antiviral drug and drug composition thereof

The invention relates to an antiviral drug and a drug composition thereof, specially relates to a drug against human immunodeficiency virus (HIV) and a drug composition thereof, and particularly relates to a drug capable of serving as a retrovirus proteas

COMPOUNDS AND METHODS FOR TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS

Small molecule compounds are provided for treating lupus as are methods of treating lupus using these compounds.

Synthesis of new thienyl ring containing HIV-1 protease inhibitors: Promising preliminary pharmacological evaluation against recombinant HIV-1 proteases

A series of new thienyl ring containing analogues of nelfinavir and saquinavir with different, substitution patterns were synthesized from suitable enantiopure diols. Their inhibitory activity against wild type recombinant HIV-1 protease was evaluated. In general thienyl groups spaced from the core by a methylene group gave products showing IC50 in the nanomolar range, irrespective of the type and the substitution pattern of the heterocycle. The range of activity of the two most, active compounds is substantially maintained or even increased against two commonly selected mutants, under drug pressure, such as V32I and V82A.

Synthesis, biological activity and modelling studies of two novel anti HIV PR inhibitors with a thiophene containing hydroxyethylamino core

An efficient method has been developed for the synthesis of a versatile intermediate bearing azido, hydroxyl and ester functions, a useful precursor for peptidomimetic compounds. The two main features for this synthesis were the use of the Sharpless asymm

Synthesis of the HIV-proteinase inhibitor Saquinavir: A challenge for process research

The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir (1), a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.

Inhibitors of HIV protease

The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating HIV infection.