methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

Base Information

Chemical Name:methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide
CAS No.:126623-90-3
Molecular Formula:C₂₀H₁₇N₃O₅S
Molecular Weight:411.438
Hs Code.:

Synonyms:methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

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Chemical Property of methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

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Technology Process of methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

There total 7 articles about methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 126623-89-0
methyl 1,5-dihydro-7-hydroxy-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

: 74-88-4
methyl iodide

: 126623-90-3
methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) 20 deg C, 1 h; 2.) 10 min;
DOI:10.1002/hlca.19890720630

Reference yield:

: 6513-21-9
3-[2-(ethoxycarbonylmethyl-carbamoyl)-ethyl-disulfanyl]propionylamino acetic acid ethyl ester

: 126623-90-3
methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / SO₂Cl₂ / 1,2-dichloro-ethane / 2.5 h / Ambient temperature

2: 78 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

3: 50 percent / Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

4: 25 percent / conc. H₂SO₄, 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 2 h / Heating

5: 90 percent / methanol; diethyl ether / 0.08 h / 20 °C

6: 70 percent / NaOMe / pyridine / 7 h / 45 °C

7: 85 percent / NaH / dimethylformamide / 1.) 20 deg C, 1 h; 2.) 10 min

With sulfuryl dichloride; sulfuric acid; sodium methylate; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19890720630

Reference yield:

: 126623-60-7
ethyl <3-oxo-2H-isothiazol-2-yl>acetate 1,1-dioxide

: 126623-90-3
methyl 1,5-dihydro-7-hydroxy-5-methyl-1,3-diphenylpyrazolo<3,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: 25 percent / conc. H₂SO₄, 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran / 2 h / Heating

3: 90 percent / methanol; diethyl ether / 0.08 h / 20 °C

4: 70 percent / NaOMe / pyridine / 7 h / 45 °C

5: 85 percent / NaH / dimethylformamide / 1.) 20 deg C, 1 h; 2.) 10 min

With sulfuric acid; sodium methylate; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19890720630