(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

Base Information

Chemical Name:(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone
CAS No.:80359-72-4
Molecular Formula:C₁₆H₂₈OSSi
Molecular Weight:296.549
Hs Code.:

Synonyms:(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

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Chemical Property of (R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

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Technology Process of (R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

There total 4 articles about (R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 80359-71-3
2-(2-Trimethylsilanylmethyl-cyclohex-2-enylsulfanyl)-cyclopentanone

: 74-88-4
methyl iodide

: 80359-73-5
(R)-2-Methylsulfanyl-2-((R)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

: 80359-72-4
(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

Guidance literature:: With potassium hydride; In 1,2-dimethoxyethane; Ambient temperature;
DOI:10.1021/ja00367a056

Reference yield:

: 20461-30-7
2-methylcyclohex-2-en-1-ol

: 80359-72-4
(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-C₄H₉Li, TMEDA, 2.) 1percent H₂SO₄ / 1.) hexane, 0 deg C, 2.) H₂O, THF, room temperature

2: 1.) n-C₄H₉Li, CS₂, CH₃I, 2.) LAH / 1.) ether, room temperature -> 60 deg C, 2.) ether, reflux

3: 67 percent / NaH / dimethylformamide / 0 deg C; room temperature

4: 70 percent / KH / 1,2-dimethoxy-ethane / Ambient temperature

With carbon disulfide; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; potassium hydride; sodium hydride; methyl iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00367a056

Reference yield:

: 80359-70-2
2-<(trimethylsilyl)methyl>-2-cyclohexen-1-ol

: 80359-72-4
(R)-2-Methylsulfanyl-2-((S)-2-trimethylsilanylmethyl-cyclohex-2-enyl)-cyclopentanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-C₄H₉Li, CS₂, CH₃I, 2.) LAH / 1.) ether, room temperature -> 60 deg C, 2.) ether, reflux

2: 67 percent / NaH / dimethylformamide / 0 deg C; room temperature

3: 70 percent / KH / 1,2-dimethoxy-ethane / Ambient temperature

With carbon disulfide; lithium aluminium tetrahydride; n-butyllithium; potassium hydride; sodium hydride; methyl iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00367a056