4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

Base Information

Chemical Name:4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt
CAS No.:1235330-62-7
Molecular Formula:C₂₅H₂₇N₅O₅S₂*H₃N
Molecular Weight:558.682
Hs Code.:

Synonyms:4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

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Chemical Property of 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

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Technology Process of 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

There total 10 articles about 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₇N₅O₂S

: 1235330-62-7
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

Guidance literature:: C₂₅H₂₇N₅O₂S; With pyridine-SO₃ complex; In pyridine; at 20 ℃; for 0.0833333h;

With ammonium hydroxide; In pyridine; water;

Reference yield:

: 1000394-68-2
N-[(S)-1-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamide

: 1235330-62-7
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; tin(ll) chloride / 4 h / Reflux

1.2: 1 h

2.1: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; ethanol; sulfur trioxide pyridine complex; tin(ll) chloride;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1235330-62-7
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenylpropanamido]ethyl}phenylsulfamic acid ammnonium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: Lawessons reagent / tetrahydrofuran / 3 h / 20 °C

3.1: acetonitrile / 3 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium carbonate / toluene / Reflux

6.1: ethanol; tin(ll) chloride / 4 h / Reflux

6.2: 1 h

7.1: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With Lawessons reagent; 4-methyl-morpholine; pyridine; ethanol; sulfur trioxide pyridine complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;